Key result
Foot-and-mouth disease virus maintains high genetic stability during persistent buffalo infections with <2.5% divergence.
Population
12 sub-clinically infected Asian water buffalos (Bubalus bubalis) from 30 dairy farms near Islamabad, Pakistan
Design
Preclinical
Follow-up
up to 1 year
Authors
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Supports FMDV stability in natural hosts; leaves open implications for persistence mechanisms and livestock control strategies.
Observational (n=12)
FMDV shows low inter- and intra-host genomic variability under established persistence in naturally infected Asian buffalo, with evidence of purifying selection.
Ramírez-Carvajal et al. (2018) conducted an observational in Foot-and-mouth disease virus (FMDV) persistent infection (n=12). Natural FMDV infection was evaluated on Intra-host viral genetic divergence. During persistent infections in naturally infected Asian buffalo, foot-and-mouth disease virus exhibited high genetic stability with long-term intra-host viral genetic divergence of less than 2.5%.
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