Neutralization kinetics can quantitatively differentiate foot-and-mouth disease virus strains, identifying Moz 1/70 as a broadly reactive candidate for vaccine production in Africa.
May guide African FMD vaccine strain selection; leaves open field efficacy before any practice change.
A comparison of homologous and heterologous rates of neutralization demonstrated that antigenic relationships of foot-and-mouth disease virus strains could be differentiated quantitatively by the kinetics of neutralization method described previously (Rwysed this way gave R values which were similar to those obtained with other neutralization test methods but which were generally smaller than those obtained with complement fixation test results. It was demonstrated that there were wide differences between the vaccine strains tested as demonstrated by R value relationships. An examination of r values, however, demonstrated that antisera to the Moz 1/70 strain were highly reactive with most of the virus strains from Central and Southern Africa. The selection of FMD virus strains with a wide serological range for vaccine production is discussed.
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Rweyemamu et al. (1977) studied this question.
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