The study characterizes the complex, non-rectilinear neutralization kinetics of foot-and-mouth disease virus type SAT 2 and identifies factors that modulate this process.
Should not yet inform neutralization strategies; leaves open in vivo relevance and translational applications.
A study of the kinetics of inactivation of foot-and-mouth disease virus type SAT 2 strains revealed that in most cases the rate of neutralization was not rectilinear. Deviations from first-order kinetics observed represented biphasic or parabolic and stepwise reactions. The initial rate was rapid and showed no lag phase or shoulder. The effects of deviations from linearity could be minimized by dilution of antiserum to a suitable extent. Treatment of virus-antibody mixtures with anti-species globulin resulted in enhancement of the rate of neutralization of homologous and heterologous reactions without significantly altering the relation between the two. This treatment also considerably reduced the amount of the persistent fraction. In attempt to disaggregate virus it was observed that sodium dodecyl sulphate inhibited neutralization of virus by specific antiserum.
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Rweyemamu et al. (1977) studied this question.
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