Modeling and Computer Simulation Approach to the Mechanism of Foot‐and‐Mouth Disease Virus Neutralization Assays

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Population

Foot-and-mouth disease virus neutralization assays (suckling mice, tissue culture, and bovine tongue models)

Design

Preclinical

Authors

Discussion

Estimates of FMDV neutralization sites are hypothesis-generating; prospective studies needed before informing antibody or vaccine strategies.

Population

Foot-and-mouth disease virus neutralization assays (suckling mice, tissue culture, and bovine tongue models)

Intervention

Computer simulation and mass-action theory modeling of neutralization assays

Outcome

Number of critical sites on the virion required for infectivity and deathsurrogate

This modeling study estimates the number of critical neutralization sites on the foot-and-mouth disease virion for IgG and IgM antibodies.

Trautman et al. (1977) studied this question.

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Estimates of FMDV neutralization sites are hypothesis-generating; prospective studies needed before informing antibody or vaccine strategies.