Key result
The abstract introduces the development of an ELISA using bovine monoclonal antibodies for detecting FMD virus neutralizing antibodies, but reports no quantitative results.
Why the study?
Detecting neutralizing antibodies against foot-and-mouth disease virus serotype O currently relies on cell culture-based virus neutralization tests, which are laborious, time-consuming, and require biocontainment facilities.
Bovine mAb-based ELISA for FMDV NAbs lacks performance data; leaves open validation before any diagnostic consideration.
Vaccination with inactivated vaccines is still the main measure to control foot-and-mouth disease (FMD) in areas where the disease is endemic, and the level of neutralizing antibody in vaccinated animals is directly related to their protection against virus challenge. Currently, neutralizing antibody is mainly detected using the virus neutralization test (VNT) based on cell culture, which is laborious and time-consuming and requires restrictive biocontainment facilities.
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Cao et al. (2019) studied Foot-and-mouth disease (FMD). Enzyme-Linked Immunosorbent Assay (ELISA) vs. Virus neutralization test (VNT) was evaluated. The abstract introduces the development of an ELISA using bovine monoclonal antibodies for detecting FMD virus neutralizing antibodies, but reports no quantitative results.
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