Different immunological methods (cross-CF, cross-neutralization, cross-protection) are all capable of differentiating FMDV strains, likely measuring the same antigen/antibody interactions.
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Multiple serological assays differentiate FMDV strains equivalently; leaves open relative field utility versus complement-fixation.
Two FMDV strains which had been previously differentiated by complement-fixation were compared by guinea-pig protection test, kinetic neutralization and micro-neutralization tests. It was found that these tests, which have not been previously applied by the methods described, were all capable of FMDV strain differentiation. Similar differences were found by all methods, which suggests that comparisons made by cross-CF, cross-neutralization or cross-protection involve measurement of the same antigen/antibody interactions.
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A. J. Forman (1975) studied this question.
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