While microplate tests are satisfactory for routine differentiation of foot-and-mouth disease virus strains, tube tests are more reproducible and provide a more precise method for identifying small antigenic differences.
Tube tests' superior reproducibility supports preference for precise antigenic differentiation; leaves open microplate optimization for routine FMDV strain identification.
Several foot-and-mouth disease virus strains were examined by complement-fixation tests in microplates and in tubes. It was established that the two systems are comparable, although greater reproducibility is obtained with tube tests. While microplate tests are a satisfactory method for the differentiation of strains, tube tests provide a more precise method for the identification of small antigenic differences.
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A. J. Forman (1974) studied this question.
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