Key result
The assumption of direct proportionality between the amount of complement fixed and the amount of antiserum reacting with constant antigen is incorrect, prompting a new method for FMDV strain differentiation.
The study demonstrates that complement fixation by FMDV antigen/antibody mixtures does not follow direct proportionality, proposing a new method for quantitative differentiation of viral strains.
Assumption of direct proportionality in FMDV complement fixation is incorrect; challenges prior models and leaves open validation of alternatives.
An examination was made of the relations between antigen, antibody and fixation of complement with foot-and-mouth disease virus (FMDV). It was found that complement fixation in this system follows the same principles as models developed in other antigen/antibody systems. The assumption that there is a relation of direct proportionality between the amount of complement fixed and the amount of antiserum reacting with constant antigen was found to be incorrect. An alternative method was proposed for the quantitative differentiation of FMDV strains by comparing the titres of an antiserum when reacting with optimum amounts of homologous or heterologous antigens.
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A. J. Forman (1974) studied Foot-and-mouth disease virus. Complement fixation test was evaluated on Relation between antigen, antibody and fixation of complement. The assumption of direct proportionality between the amount of complement fixed and the amount of antiserum reacting with constant antigen is incorrect, prompting a new method for FMDV strain differentiation.
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