Key result
The FMDV O/Fujian/CHA/5/99 strain isolated from swine showed higher virulence in suckling mice (LD50 = 10^-8.3) compared to the bovine-isolated O/Tibet/CHA/1/99 strain (LD50 = 10^-7.0).
Population
3-day-old suckling mice and BHK-21 cells
Comparison
Infection with FMDV swine-isolated… vs Infection with FMDV bovine-isolated…
Design
Preclinical
Follow-up
72 hours
Authors
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Swine-derived FMDV shows higher murine virulence; leaves open strain-specific adaptation mechanisms for livestock surveillance.
The FMDV O/Fujian/CHA/5/99 strain exhibits high virulence in suckling mice and distinct plaque morphology, likely driven by specific amino acid substitutions in the viral capsid and IRES.
Bai et al. (2010) studied Foot-and-Mouth Disease Virus (FMDV). FMDV O/Fujian/CHA/5/99 strain vs. FMDV O/Tibet/CHA/1/99 strain was evaluated on Pathogenicity in suckling mice (LD50). The FMDV O/Fujian/CHA/5/99 strain isolated from swine showed higher virulence in suckling mice (LD50 = 10^-8.3) compared to the bovine-isolated O/Tibet/CHA/1/99 strain (LD50 = 10^-7.0).
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