Key result
A strain of FMDV isolated from naturally infected pigs in China was identified as serotype Asia1, with its genome showing a close genetic relationship and potential recombination with JS/CHA/05 and HNK/CHA/05 strains.
This is the first report of the isolation and identification of a strain of FMDV type Asia1 from naturally infected pigs, revealing its genomic features and potential recombination origins.
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Extends Asia1 FMDV host range to pigs; leaves open recombination surveillance priorities.
BACKGROUND: Foot-and-mouth disease virus (FMDV) serotype Asia1 generally infects cattle and sheep, while its infection of pigs is rarely reported. In 2005-2007, FMD outbreaks caused by Asia1 type occurred in many regions of China, as well as some parts of East Asia countries. During the outbreaks, there was not any report that pigs were found to be clinically infected. RESULTS: In this study, a strain of FMDV that isolated from pigs was identified as serotype Asia1, and designated as "Asia1/WHN/CHA/06". To investigate the genomic feature of the strain, complete genome of Asia1/WHN/CHA/06 was sequenced and compared with sequences of other FMDVs by phylogenetic and recombination analysis. The complete genome of Asia1/WHN/CHA/06 was 8161 nucleotides (nt) in length, and was closer to JS/CHA/05 than to all other strains. Potential recombination events associated with Asia1/WHN/CHA/06 were found between JS/CHA/05 and HNK/CHA/05 strains with partial 3B and 3C fragments. CONCLUSION: This is the first report of the isolation and identification of a strain of FMDV type Asia1 from naturally infected pigs. The Asia1/WHN/CHA/06 strain may evolve from the recombination of JS/CHA/05 and HNK/CHA/05 strains.
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Yang et al. (2011) studied Foot-and-mouth disease (n=3). FMDV serotype Asia1 infection was evaluated on Complete genome sequence and phylogenetic analysis. A strain of FMDV isolated from naturally infected pigs in China was identified as serotype Asia1, with its genome showing a close genetic relationship and potential recombination with JS/CHA/05 and HNK/CHA/05 strains.
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