January 1, 2018Journal of Veterinary Medical ScienceOpen Access

Early pathogenesis of the foot-and-mouth disease virus O/JPN/2010 in experimentally infected pigs

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Population

13 pigs aged 24 days old

Comparison

Intraoral inoculation with 10^6 TCID50/ml or… vs Non-infected control (n=1)

Design

Preclinical

Follow-up

up to 6 days

Authors

MYManabu YamadaKagawa University KFKatsuhiko FukaiNational Agriculture and Food Research Organization KMKazuki MoriokaNational Agriculture and Food Research Organization

Discussion

Member takes

Implication

Early FMDV lesions at 3 dpi in pigs support targeted sampling; leaves open validation for natural outbreaks and diagnostics.

Structured PICO

Population

13 pigs aged 24 days old (1 non-infected control, 6 inoculated with 10^6 TCID50/ml, 6 inoculated with 10^3 TCID50/ml)

Intervention

Intraoral inoculation with 10^6 TCID50/ml or 10^3 TCID50/ml of FMDV O/JPN/2010

Comparator

Non-infected control (n=1)

Outcome

Histological distribution of lesions and viral antigen in multisystemic organssurrogate

FMDV O/JPN/2010 predominantly infects prickle cells in the stratum spinosum of the tongue and feet in pigs at high doses, causing apoptosis without infecting basal cells.

Cite This Study

Yamada et al. (2018) studied this question.

synapsesocial.com/papers/6a720eb0f44fa9f079dfaa93 https://doi.org/10.1292/jvms.17-0683

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Early pathogenesis of the foot-and-mouth disease virus O/JPN/2010 in experimentally infected pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Early pathogenesis of the foot-and-mouth disease virus O/JPN/2010 in experimentally infected pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider