Key result
Vaccination with FMD O1Manisa vaccine significantly reduced the detection of FMDV RNA in pig tonsils 30-32 days post-infection compared to non-vaccinated controls (8.0% vs 35.5%, P=0.024).
Why the study?
Does vaccination reduce the detection of FMDV RNA in tonsils of pigs 31 to 32 days after infection?
Population
56 pigs (10 weeks of age) infected with FMDV O/NET/2001
Comparison
Vaccination with double oil emulsion FMD… vs Non-vaccinated control animals
Design
Preclinical
Follow-up
31 to 32 days
Authors
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Supports evaluation of FMD vaccination to limit viral persistence in pigs; leaves open effects on transmission and field efficacy.
Does vaccination reduce the detection of FMDV RNA in tonsils of pigs 31 to 32 days after infection?
Absolute Event Rate: 8% vs 35.5%
p-value: p=0.024
Vaccination significantly reduced the detection of FMDV RNA in the tonsils of pigs 4 weeks after infection, though no viable virus was isolated.
Orsel et al. (2008) studied Foot-and-mouth disease (FMD) (n=56). FMD O1Manisa vaccine vs. Non-vaccinated control animals was evaluated on Detection of FMDV RNA in tonsils by RT-PCR (p=0.024). Vaccination with FMD O1Manisa vaccine significantly reduced the detection of FMDV RNA in pig tonsils 30-32 days post-infection compared to non-vaccinated controls (8.0% vs 35.5%, P=0.024).
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