Key result
Elevated serum IGF-1 levels predicted treatment resistance in schizophrenia, though lipid and glucose metabolism did not show an observable effect on retinal neural thinning.
Why the study?
The effects of metabolic changes on neural structures in the later stages of schizophrenia remain unknown, and alterations in glucose and lipid metabolism could impact disease progression.
Cross-Sectional (n=122)
No
While treatment-resistant schizophrenia is associated with neural thinning as measured by OCT, this phenomenon does not appear to be driven by alterations in glucose or lipid metabolism.
Answers are grounded in this paper and cite their sources.
May link metabolic changes to retinal thinning in treatment-resistant schizophrenia; leaves open causal role and clinical utility.
Objective:The effects of metabolic changes on neural structures in the later stages of schizophrenia remain unknown.Alterations in glucose and lipid metabolism could impact disease progression.This study aims to investigate the effects of glucose and lipid metabolism on neuronal structures in treatment-resistant schizophrenia using optical coherence tomography (OCT), glycogenic proteins, and cholesterol values. Method:The study included 39 schizophrenia patients with remission, 43 treatment-resistant schizophrenia (TRS) patients, and 40 healthy controls (HC).Optical coherence tomography (OCT) was performed on all participants.Serum samples were collected to determine fasting glucose, Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), triglycerides, total cholesterol, fasting insulin, and Insulin-like Growth Factor 1 (IGF-1) levels.Results: IGF-1 levels in TRS patients were higher than those in the remission group.Additionally, the thickness of the inferior retinal nerve fiber layer (RNFL), superior RNFL, and global RNFL regions was significantly lower in the TRS group than in the HC group. Conclusion:While OCT measurements and elevated IGF-1 levels indicate neural thinning in treatment-resistant schizophrenia, there was no observed effect from lipid and glucose metabolism on this phenomenon.
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Ümit Haluk Yeşilkaya (2023) conducted a cross-sectional in Treatment-resistant schizophrenia (n=122). Serum IGF-1 levels was evaluated on Prediction of treatment resistance by serum IGF-1 levels (OR 1.033, 95% CI 1.012-1.053, p=0.002). Elevated serum IGF-1 levels predicted treatment resistance in schizophrenia, though lipid and glucose metabolism did not show an observable effect on retinal neural thinning.
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