Evidence for an Internal Antigen in Foot-and-Mouth Disease Virus

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Population

Foot-and-mouth disease virus grown in baby hamster kidney cells; hyperimmunized infected guinea pigs

Comparison

Disruption of the virus vs Intact virus (25 nm component)

Design

Preclinical

Authors

Discussion

Reveals internal FMDV antigen upon disruption; leaves open implications for heterotypic serology or vaccines in livestock.

Population

Foot-and-mouth disease virus grown in baby hamster kidney cells; hyperimmunized infected guinea pigs

Intervention

Disruption of the virus (via storage at 4°C, heating at 37°C, mixing with cells, or guanidine)

Comparator

Intact virus (25 nm component)

Outcome

Complement fixation with heterotypic and homotypic antiserasurrogate

Demonstrates the presence of an internal structural antigen in foot-and-mouth disease virus that is exposed upon viral disruption.

Rowlands et al. (1969) studied this question.

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