June 1, 1987Journal of General Virology

Surface Structure and RNA-Protein Interactions of Foot-and-Mouth Disease Virus

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Population

Foot-and-mouth disease virus (FMDV) particles and 12S protein subunit

Design

Preclinical

Authors

DMDavid J. MorrellCatalyst Pharmaceuticals (United States)EMEdward MellorThe Pirbright Institute DRDavid J. RowlandsUniversity of Leeds

Discussion

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Implication

May guide FMDV capsid engineering for vaccines; leaves open functional roles of lysine-RNA cross-links in vivo.

Structured PICO

Population

Foot-and-mouth disease virus (FMDV) particles and 12S protein subunit

Intervention

Modification reagents (Bolton & Hunter reagent, sodium metabisulphite, trypsin)

Outcome

Extent of modification of lysine residues and cross-linking of structural proteins to virus RNA

The study maps the surface lysine residues of FMDV capsid proteins and demonstrates their cross-linking to viral RNA, proposing a structural model for VP1.

Cite This Study

Morrell et al. (1987) studied this question.

synapsesocial.com/papers/6a6f56d02163a0a01bc3a6ba https://doi.org/10.1099/0022-1317-68-6-1649

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Surface Structure and RNA-Protein Interactions of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Surface Structure and RNA-Protein Interactions of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider