Answers are grounded in this paper and cite their sources.
To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.
No takes yet. Share an insight, caveat, or question.
Spotswood L. Spruance (1988) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: