Key result
Indigenous cattle breeds, particularly Malnad Gidda, mounted potent innate antiviral and cell-mediated immune responses that significantly restricted FMDV replication during acute infection.
Why the study?
Foot-and-mouth disease virus causes severe infection in ruminants, prompting an investigation into host-pathogen molecular interactions to aid prevention and control strategies.
Population
Cattle experimentally infected with FMDV including Malnad Gidda, Hallikar, and Holstein Friesian crossbred calves
Comparison
Two Indian cattle breeds vs Holstein Friesian crossbred calves
Design
Experimental infection and transcriptional analysis study
Authors
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May guide breed-specific FMDV strategies in cattle; leaves open validation for broader antiviral applications.
Induction of potent innate antiviral response and cell-mediated immunity in indigenous Indian cattle significantly restricts FMDV replication during acute infection.
Saravanan et al. (2021) studied Foot-and-mouth disease virus (FMDV) infection. Indigenous cattle breeds (Malnad Gidda and Hallikar) vs. Holstein Friesian (HF) crossbred calves was evaluated on Viral load and immune response (transcriptional analysis). Indigenous cattle breeds, particularly Malnad Gidda, mounted potent innate antiviral and cell-mediated immune responses that significantly restricted FMDV replication during acute infection.
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