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May 21, 2015PLoS ONEOpen Access

Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression

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Key result

In cattle persistently infected with foot-and-mouth disease virus, viral detection was highest in the dorsal nasopharynx (80.95%) and dorsal soft palate (71.43%), with a trend toward decreased local cytokine mRNA expression.

Authors

JPJuan M. PachecoSaint Joseph's UniversityGSGeorge R. SmoligaPlum Island Animal Disease CenterVOVivian O’DonnellAnimal and Plant Health Inspection Service

Discussion

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Overview

May refine FMDV surveillance strategies in cattle; leaves open cytokine roles in persistence.

PICO

P
Population
21 Holstein steers, 9 to 12 months old, persistently infected with Foot-and-Mouth Disease Virus, evaluated for tissue-specific viral localization and cytokine expression up to 52 days post-inoculation.
E
Exposure / Comparator
FMDV persistent infection vs Uninfected control animals
O
Primary Outcome
Prevalence of overall viral detection in the dorsal nasopharynx

Limitations

  • Lack of statistically significant differences in cytokine mRNA transcription between carriers and uninfected control animals.
  • Variation in experimental designs, FMDV strains, and inoculation routes may affect comparability with other studies.

Cite This Study

Pacheco et al. (2015) studied Foot-and-Mouth Disease Virus (FMDV) persistent infection (n=21). FMDV persistent infection vs. Uninfected control animals was evaluated on Prevalence of overall viral detection in the dorsal nasopharynx. In cattle persistently infected with foot-and-mouth disease virus, viral detection was highest in the dorsal nasopharynx (80.95%) and dorsal soft palate (71.43%), with a trend toward decreased local cytokine mRNA expression.

synapsesocial.com/papers/6a6f58fb6ceb2bbd16dfa63ehttps://doi.org/10.1371/journal.pone.0125698
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Also Consider

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  1. 1Viral strategies for evading antiviral cellular immune responses of the host2005 · 111 citations
  2. 2Foot-and-Mouth Disease Virus Replicates Only Transiently in Well-Differentiated Porcine Nasal Epithelial Cells2010 · 22 citations
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  4. 4Inoculation of Swine with Foot-and-Mouth Disease SAP-Mutant Virus Induces Early Protection against Disease2011 · 45 citations
  5. 5A new mathematical model for relative quantification in real-time RT-PCR2001 · 35,343 citations