Key result
Foot-and-mouth disease virus RNA peaked by day 1 post-infection in lesion sites and persisted beyond 28 days in pharyngeal tissues, correlating with infectious virus in oesophageal-pharyngeal fluid.
Population
Bovine tissues during acute and persistent stages of foot-and-mouth disease virus (FMDV) infection
Design
Preclinical
Follow-up
Beyond 28 days post-infection
Authors
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Highlights pharyngeal tissues as FMDV persistence sites in this model; leaves open roles in transmission and needs validation in natural hosts.
FMDV RNA persists in pharyngeal region tissues beyond 28 days post-infection, indicating specific tissue sites of viral persistence.
Zhang et al. (2004) studied Foot-and-mouth disease (FMD). Foot-and-mouth disease virus (FMDV) infection was evaluated on Viral RNA levels in various bovine tissues. Foot-and-mouth disease virus RNA peaked by day 1 post-infection in lesion sites and persisted beyond 28 days in pharyngeal tissues, correlating with infectious virus in oesophageal-pharyngeal fluid.
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