Key result
Unvaccinated cattle excreted significantly higher levels of foot-and-mouth disease virus for longer periods compared with vaccinated cattle (p<0.001), independent of whether they subsequently became carriers.
Population
100 cattle
Comparison
FMDV challenge vs Vaccinated vs unvaccinated cattle; carrier vs…
Design
Preclinical
Follow-up
up to 168 days post-challenge
Authors
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Supports vaccination to limit FMDV shedding in cattle; leaves open effects on transmission and control programs.
p-value: p=<0.001
Vaccination reduces FMDV viral shedding duration and levels in cattle, and the risk of transmission from carrier cattle to naïve animals is very low under controlled conditions.
Parthiban et al. (2015) studied Foot-and-mouth disease (n=100). FMDV vaccination vs. Unvaccinated was evaluated on Viral shedding (peak, total, and duration) in nasal fluid and saliva (p=<0.001). Unvaccinated cattle excreted significantly higher levels of foot-and-mouth disease virus for longer periods compared with vaccinated cattle (p<0.001), independent of whether they subsequently became carriers.
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