Key result
The 2014-2015 type O foot-and-mouth disease outbreak in Korea resulted in 185 cases, caused by a newly introduced South-East Asia topotype strain featuring a unique deletion in the 5' non-coding region.
Observational (n=172,734)
The 2014-2015 FMD outbreak in Korea was caused by a newly introduced strain with a unique 5' non-coding region deletion, affecting mostly pigs despite vaccination.
Alerts to novel FMD strain emergence; leaves open questions on deletion's role in spread and control.
On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak began in Korea. Although vaccinations were administered, FMD cases increased steadily for five months, and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccination. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea between April 2010 and July 2014. However, the FMD virus isolated in December 2014 had a unique feature; that is, partial deletion of the 5´ non-coding region, a deletion not seen in previous SEA topotype isolates identified in Korea. We conclude that this outbreak included the introduction of a new FMD strain to Korea, and that Korea was now affected by genetically similar FMD virus strains that are related to those from neighboring countries.
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Park et al. (2018) conducted an observational in Foot-and-mouth disease (FMD) (n=172,734). Type O foot-and-mouth disease virus (O/SKR/Dec/2014) was evaluated on Number of FMD cases and genetic characterization of the virus. The 2014-2015 type O foot-and-mouth disease outbreak in Korea resulted in 185 cases, caused by a newly introduced South-East Asia topotype strain featuring a unique deletion in the 5' non-coding region.
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