What question did this study set out to answer?

The aim was to determine if liver fatty acid-binding protein (L-FABP) regulates long chain fatty acid distribution to the nucleus.

August 1, 2002Journal of Biological ChemistryOpen Access

Liver Fatty Acid-binding Protein Targets Fatty Acids to the Nucleus

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The aim was to determine if liver fatty acid-binding protein (L-FABP) regulates long chain fatty acid distribution to the nucleus.
L-cell fibroblasts were transfected to overexpress L-FABP.
Fluorescent fatty acids of varying chain lengths were used for uptake experiments with real-time microscopy.
L-FABP expression increased long and medium chain fatty acid uptake by 2-4-fold.
Long and medium chain fatty acids targeted to the nucleus by 2.9-4.4-fold compared to short chain.
Nuclear:cytoplasm ratio increased by 2-3.6-fold for medium and long chain fatty acids.

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Implication

Randomized trial investigates liver fatty acid-binding protein's role in fatty acid nuclear targeting, suggesting new pathways for fatty acid regulation.

Cite This Study

Huang et al. (2002) studied this question.

synapsesocial.com/papers/6a6f580635aa2c282ce0b8cb https://doi.org/10.1074/jbc.m202923200

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Implication

Randomized trial investigates liver fatty acid-binding protein's role in fatty acid nuclear targeting, suggesting new pathways for fatty acid regulation.

Liver Fatty Acid-binding Protein Targets Fatty Acids to the Nucleus

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Discussion

Implication

Cite This Study

Liver Fatty Acid-binding Protein Targets Fatty Acids to the Nucleus

Key Points

Discussion

Implication

Cite This Study

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