Why the study?
Does 50 microgram/kg fentanyl prevent the metabolic and hormonal response to gynaecological surgery compared to halothane?
Does 50 microgram/kg fentanyl prevent the metabolic and hormonal response to gynaecological surgery compared to halothane?
Answers are grounded in this paper and cite their sources.
Large doses of fentanyl can inhibit the cortisol and growth hormone response to surgery, potentially ameliorating the catabolic response to surgical trauma.
A study was undertaken in twenty-eight patients to compare the effects of the supplementation of nitrous oxide and oxygen anaesthesia with either 0.5--1.0% halothane or 50 microgram fentanyl/kg on the metabolic and hormonal response to gynaecological surgery. The results showed that the increases in blood glucose, plasma cortisol and growth hormone concentrations observed in the halothane group of patients were abolished in those who received fentanyl. It is postulated that the ability of large doses of fentanyl to inhibit the cortisol and growth hormone response to surgery may be of value in ameliorating the catabolic response to trauma.
No takes yet. Share an insight, caveat, or question.
Hall et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: