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April 4, 2017PLoS ONEOpen Access

A novel enterovirus species identified from severe diarrheal goats

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Key result

A novel enterovirus, CEV-JL14, was identified from goats with severe diarrhea and proposed as a new Enterovirus species L based on complete genomic sequencing and phylogenetic analysis.

Population

Goats manifesting severe diarrhea with morbidity up to 84% and mortality up to 54% in China

Comparison

Virology, molecular and bioinformatics… vs Known Enterovirus species

Design

Preclinical

Authors

MWMingyue WangZhejiang Normal UniversityJHJia HeGuangxi UniversityHLHaibing LuAnhui Jianzhu University

Discussion

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Implication

Warrants livestock surveillance; leaves open zoonotic risk and species validation.

Structured PICO

P
Population
76 goats from a farm in China experiencing an outbreak of severe diarrhea and respiratory distress with 84% morbidity and 54% mortality, from which 4 were sampled for virus isolation.
E
Exposure
Virology, molecular and bioinformatics characterization of enterovirus CEV-JL14
C
Comparator
Known Enterovirus species (including TB4-OEV, Enterovirus A-G)
O
Outcome
Genomic sequence identity and phylogenetic clusteringsurrogate

Identification of CEV-JL14 as a novel caprine enterovirus species L broadens the understanding of enterovirus genetic variations in small ruminants.

Limitations

  • Lack of enough ovine/caprine enterovirus sequences for broader comparison
  • Mechanism underlying the involvement of enteroviruses in the severe respiratory and digestive diseases remains unexplored

Cite This Study

Wang et al. (2017) studied Severe diarrhea and respiratory distress (n=76). CEV-JL14 (novel enterovirus) was evaluated on Genomic characterization and phylogenetic classification. A novel enterovirus, CEV-JL14, was identified from goats with severe diarrhea and proposed as a new Enterovirus species L based on complete genomic sequencing and phylogenetic analysis.

synapsesocial.com/papers/6a6f585035aa2c282ce0b998https://doi.org/10.1371/journal.pone.0174600
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Also Consider

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  1. 1Genetic variations in regions of bovine and bovine-like enteroviral 5’UTR from cattle, Indian bison and goat feces2016 · 12 citations
  2. 2Molecular Identification and Characterization of a New Type of Bovine Enterovirus2012 · 15 citations
  3. 3Natural interspecies recombinant bovine/porcine enterovirus in sheep2012 · 96 citations
  4. 4First Identification and Characterization of Porcine Enterovirus G in the United States2014 · 54 citations
  5. 5Survey of Bovine Enterovirus in Biological and Environmental Samples by a Highly Sensitive Real-Time Reverse Transcription-PCR2005 · 103 citations