Key result
Phylogenetic analyses of 32 EV71 isolates from the United Kingdom between 1998 and 2006 identified genotype C as the dominant strain, with continuous circulation and repeated introductions of new strains.
Observational (n=32)
Yes
EV71 genotype C was the dominant strain circulating in the UK from 1998 to 2006, highlighting the need for continuous monitoring of its molecular evolution.
Genomic surveillance of EV71 remains essential; extends UK historical data but is hypothesis-generating for strain evolution and outbreaks.
The last decade witnessed a significant increase in epidemic activity of human enterovirus 71 (EV71) in the Western Pacific Region (WPR). In most European countries, this risk is unrecognized despite occasional cases of severe disease and two severe outbreaks in Eastern Europe 30 years ago. In this study we report the first examination of the molecular epidemiology of EV71 in the United Kingdom from 1998 to 2006. Genomic regions encoding the 1D coat protein (VP1) and 3D polymerase (Pol) from 32 EV71 isolates associated with neurological or cutaneous manifestations were sequenced. Phylogenetic analyses of VP1 and 3D Pol sequences identified genotype C as the dominant strain. Several United Kingdom isolates had genetic linkages with predated C1 or C2 strains from Europe and the WPR. Recombination events were not detected between United Kingdom strains. However, a previously published Taiwanese strain was identified as an intergenotypic recombinant. EV71 genotype C appears to have continuous circulation in the United Kingdom from 1998 to 2006 with repeated introductions of new strains replacing previous strains. It is necessary to continuously monitor the molecular evolution and recombination events of EV71.
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Bible et al. (2008) conducted an observational in Human enterovirus 71 (EV71) infection (n=32). EV71 infection was evaluated on Dominant EV71 genotype and phylogenetic relationships. Phylogenetic analyses of 32 EV71 isolates from the United Kingdom between 1998 and 2006 identified genotype C as the dominant strain, with continuous circulation and repeated introductions of new strains.
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