Key result
Treatment with an EV71-specific antibody significantly increased the survival rate of infected B-cell-deficient mice to 100% compared to 0% in those receiving a control antibody (P < 0.01).
Why the study?
Does virus-specific antibody treatment reduce mortality and tissue viral loads in EV71-infected mice?
Population
Mice infected with Enterovirus 71, and spinal cord tissue from an EV71-infected patient who died.
Comparison
Virus-specific antibody treatment vs Control antibody or wild-type mice
Design
Preclinical
Authors
Loading...
Supports EV71 antibody therapies and vaccines; leaves open human translation from this animal model.
Does virus-specific antibody treatment reduce mortality and tissue viral loads in EV71-infected mice?
Absolute Event Rate: 100% vs 0%
p-value: p=<0.01
Lymphocyte and antibody responses protect against EV71 infection, supporting the development of vaccines and virus-specific antibodies while raising caution against using corticosteroids for neurological symptoms.
Lin et al. (2009) studied Enterovirus 71 (EV71) infection. EV71-specific antibody vs. Control antibody was evaluated on Survival rate (p=<0.01). Treatment with an EV71-specific antibody significantly increased the survival rate of infected B-cell-deficient mice to 100% compared to 0% in those receiving a control antibody (P < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: