Key result
Type I interferons, induced by poly(I:C) or administered as recombinant IFN-alphaA, improved survival and decreased tissue viral titres in neonatal mice infected with enterovirus 71.
Why the study?
Do type I interferons protect against enterovirus 71 infection in a neonatal mouse model?
Do type I interferons protect against enterovirus 71 infection in a neonatal mouse model?
Type I interferons play a critical role in controlling enterovirus 71 infection and replication in a neonatal mouse model.
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Supports type I interferon exploration for neonatal EV71; leaves open translation to human infants pending clinical studies.
Liu et al. (2005) studied Enterovirus 71 (EV71) infection. Type I interferons (poly(I:C) or recombinant mouse IFN-alphaA) vs. Control mice was evaluated on Survival rate and tissue viral titres. Type I interferons, induced by poly(I:C) or administered as recombinant IFN-alphaA, improved survival and decreased tissue viral titres in neonatal mice infected with enterovirus 71.
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