Key result
Inoculation with the attenuated EV71(S1-3') strain protected cynomolgus monkeys from lethal challenge and elicited broad neutralizing activity, although it remained neurotropic.
The attenuated EV71(S1-3') strain acts as an effective antigen with broad neutralizing activity and protects against lethal challenge in monkeys, despite retaining some neurotropism.
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Supports attenuated EV71 strains in primate models; leaves open human vaccine development pending resolution of residual neurotropism.
Arita et al. (2007) studied Enterovirus 71 infection (n=5). Attenuated strain of EV71 [EV71(S1-3')] was evaluated on Survival after lethal challenge and neutralizing activity. Inoculation with the attenuated EV71(S1-3') strain protected cynomolgus monkeys from lethal challenge and elicited broad neutralizing activity, although it remained neurotropic.
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