Tetraploid Pregnancy Following a Frozen Thawed Embryo Transfer in an Intracytoplasmic Sperm Injection Cycle

ABS TRACTHere we report a case of a couple with primary infertility due to male factor.Gynecologic examination, basal hormone levels, and hysterosalpingography of the spouse were within normal limits.Sperm analyses were reported as severe oligoasthenoteratospermia. Peripheral blood karyotype analyses of the couple were normal.Controlled ovarian hyperstimulation (COH) with gonadotropins and ICSI were performed.A single frozen thawed blastocyst stage as 4AB quality embryo was transferred.The bhCG value on the 12 th day after the transfer was 444 mIU/L.Gestational sac were observed on transvaginal ultrasound on the 22 nd day following embryo transfer.At the following exams, embryo heartbeat was not detected and missed abortus was diagnosed.Pregnancy evacuation was performed during the 9th week of the pregnancy, and materials were separated for karyotyping.Cytogenetic evaluation of the conceptus was reported as tetraploidy (92,XXYY).Chromosomal segregation anomalies as mitotic failure following zygote stage can be considered for the development of multiploid embryos among ICSI cycle.