Serum Adipsin Levels of Lean and Overweight Women with Polycystic Ovary Syndrome

ABS TRACTObjective: To compare serum adipsin concentrations in underweight and overweight polycystic ovary syndrome.Materials and Methods: A total of 56 patients, 28 of whom were diagnosed with PCOS and 28 were healthy controls were included.PCOS patients were divided into two groups according to BMI values.While 14 patients with a BMI of 18.5-24.9kg/m 2 constituted the normal weight PCOS group, 14 patients with a BMI of 25-29.9kg/m 2 were considered overweight PCOS.No hyperandrogenemia, LH, FSH imbalance and PCO morphology were found in the control group.Serum adipsin concentration of both groups was measured by ELISA method.Results: Serum adipsin levels were significantly decreased in the obese PCOS group compared to lean PCOS and controls.The serum adipsin levels of the non-PCOS group showed a significant increase compared to both the lean PCOS and the obese PCOS groups.The lean PCOS group exhibited high adipsin levels compared to the obese group.There was a negative significant relationship between BMI and adipsin in both PCOS groups.The increase in BMI led to a decrease in adipsin level.A negative significant correlation was recorded between serum adipsin levels, HOMA-IR, LH and testosterone in PCOS group.Conclusions: Obesity impairs both synthesis and release of adipsin from adipose tissue of PCOS patients.