Key result
Engineered models of the human heart, including heart-on-a-chip technologies, offer promising new opportunities to study cardiac diseases beyond channelopathies.
Why the study?
Immaturity of pluripotent stem cell-derived cardiomyocytes has largely limited disease modeling to cardiac channelopathies, but recent advances in tissue engineering and organoids offer new opportunities to model broader diseases.
Design
Review
Authors
Loading...
Cardiac organoids may extend hPSC modeling beyond channelopathies; leaves open validation for broader disease applications.
Recent advances in tissue engineering and organoids offer new opportunities to study cardiac diseases beyond channelopathies using three-dimensional, personalized heart-on-a-chip models.
Stein et al. (2020) conducted a review in Cardiac diseases. Engineered models of the human heart and heart-on-a-chip technologies was evaluated. Engineered models of the human heart, including heart-on-a-chip technologies, offer promising new opportunities to study cardiac diseases beyond channelopathies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: