Key result
The A allele of the LRP6 rs2302684 polymorphism was associated with a significantly increased risk of sudden cardiac death (adjusted HR 1.783) in patients with chronic heart failure.
Why the study?
Although LRP6 deficiency is associated with arrhythmias, the association between genetic variations of LRP6 and sudden cardiac death remains unknown.
Does the A allele of LRP6 SNP rs2302684 increase the risk of sudden cardiac death and all-cause mortality in patients with chronic heart failure?
Cohort (n=1,437)
Yes
Does the A allele of LRP6 SNP rs2302684 increase the risk of sudden cardiac death and all-cause mortality in patients with chronic heart failure?
Answers are grounded in this paper and cite their sources.
The LRP6 rs2302684 T>A polymorphism is an independent predictor of all-cause mortality and sudden cardiac death in Chinese Han patients with chronic heart failure.
Low-density lipoprotein receptor-related protein 6 (LRP6) plays a critical role in cardiovascular homeostasis. The deficiency of LRP6 is associated with a high risk of arrhythmias. However, the association between genetic variations of LRP6 and sudden cardiac death (SCD) remains unknown. This study aims to explore the association between common variants of LRP6 and the prognosis of chronic heart failure (CHF) patients. From July 2005 to December 2009, patients with CHF were enrolled from 10 hospitals in China. The single-nucleotide polymorphism (SNP) rs2302684 was selected for the evaluation of the effect of LRP6 polymorphisms on the survival in patients with CHF. A total of 1,437 patients with CHF were finally included for the analysis. During a median follow-up of 61 months (range 0.4–129 months), a total of 546 (38.0%) patients died, including 201 (36.8%) cases with SCD and 345 (63.2%) cases with non-SCD. Patients carrying A allele of rs2302684 had an increased risk of all-cause death (adjusted HR 1.452, 95% CI 1.189–1.706; P < 0.001) and SCD (adjusted HR 1.783, 95% CI 1.337–2.378; P < 0.001). Therefore, the SNP rs2302684 T>A in LRP6 indicated higher risks of all-cause death and SCD in patients with CHF. LRP6 could be added as a novel predictor of SCD and might be a potential therapeutic target in the prevention of SCD in the CHF population.
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Guo et al. (2022) conducted a cohort in Chronic heart failure (n=1,437). LRP6 rs2302684 A allele vs. LRP6 rs2302684 TT genotype (wild type) was evaluated on Sudden cardiac death (HR 1.783, 95% CI 1.337-2.378, p=<0.001). The A allele of the LRP6 rs2302684 polymorphism was associated with a significantly increased risk of sudden cardiac death (adjusted HR 1.783) in patients with chronic heart failure.
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