Key result
KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits, which is necessary and sufficient to determine the slow-activation time course of I(Ks).
Population
Preclinical model expressing human I(Ks) channels (KCNQ1 pore-forming subunits and KCNE1 accessory subunits)
Comparison
Presence of KCNE1 (E1) accessory subunits vs Absence of KCNE1 accessory subunits
Design
Preclinical
Authors
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No immediate clinical implications for arrhythmia management; leaves open whether KCNE1-S4 interactions represent human therapeutic targets.
The study demonstrates that KCNE1 accessory subunits slow the activation of cardiac I(Ks) channels by directly slowing the movement of the S4 voltage sensors in KCNQ1 subunits.
Ruscic et al. (2013) studied this question. KCNE1 (E1) accessory subunits vs. Absence of KCNE1 (E1) was evaluated on S4 voltage sensor movement and I(Ks) activation time course. KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits, which is necessary and sufficient to determine the slow-activation time course of I(Ks).