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Mental illnesses like bipolar disorder and schizophrenia often present psychotic symptoms. Current antipsychotic medications, including clozapine, can cause serious side effects. This study investigates the potential therapeutic effects of the cholinesterase inhibitor donepezil compared to clozapine in a ketamine-induced psychosis model in rats. Forty adult male albino rats were divided into four groups: a control group, a psychosis group (given 25 mg/kg ketamine HCl for 14 days), a Clozapine +
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Khlood M. Mehdar (2025) studied this question.
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