Key result
Patients with post-acute sequelae of SARS-CoV-2 had significantly worse arterial elasticity compared to uninfected controls, with a mean difference in augmentation index of 11.21.
Why the study?
Post-acute sequelae of SARS-CoV-2 (PASC) presents with different phenotypes among COVID-19 survivors, but its underlying etiology remains elusive.
Does SARS-CoV-2 infection and PASC increase arterial stiffness and endothelial dysfunction in adult patients?
Population
379 COVID-negative and COVID-positive participants with and without PASC
Comparison
COVID-negative controls vs COVID-positive participants with and without PASC
Design
Prospective propensity score-matched cohort study
Authors
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Endothelial function testing may aid PASC phenotyping in survivors; leaves open causality and need for prospective trials.
Cohort (n=379)
No
Does SARS-CoV-2 infection and PASC increase arterial stiffness and endothelial dysfunction in adult patients?
Mean Difference: 11.21
Absolute Event Rate: 11.4% vs 0.18%
p-value: p=<0.0001
Post-acute sequelae of SARS-CoV-2 (PASC) is independently associated with increased arterial stiffness and elevated oxidized LDL, suggesting a role for oxidative stress and vascular changes in long COVID.
Zisis et al. (2023) conducted a cohort in Post-Acute Sequelae of SARS-CoV-2 (PASC) (n=379). SARS-CoV-2 infection with PASC vs. COVID-negative controls was evaluated on Arterial elasticity (augmentation index) (MD 11.21, p=<0.0001). Patients with post-acute sequelae of SARS-CoV-2 had significantly worse arterial elasticity compared to uninfected controls, with a mean difference in augmentation index of 11.21.
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