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April 1, 2013Diabetes Metabolic Syndrome and ObesityOpen Access

Predictors and prevention of diabetic cardiomyopathy

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Authors

PMParas K. MishraCChavaliTTyagi

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Overview

May aid staging and exercise counseling in diabetic cardiomyopathy; leaves open need for confirmatory randomized trials.

Key Points

  • To review the cellular, molecular, and metabolic predictors of diabetic cardiomyopathy and evaluate prevention strategies.
  • Synthesized literature on the clinical stages, biomolecular mechanisms, and structural remodeling underlying diabetic cardiomyopathy.
  • Evaluated the impact of lifestyle risk factors, microRNA signaling, and exercise training interventions on cardiac performance.
  • Defined three distinct progression stages: early metabolic changes, middle-stage diastolic dysfunction with ejection fraction <50% and apoptosis, and late-stage microvascular impairment leading to heart failure.
  • Identified critical molecular contributors including microRNA dysregulation, advanced glycation end products, hyperlipidemia, and extracellular matrix remodeling.
  • Demonstrated that exercise training counteracts obesity-related disease progression by improving insulin sensitivity and cardiomyocyte contractility.

Cite This Study

Mishra et al. (2013) studied this question.

synapsesocial.com/papers/6a6f5dcbe71d69abee07fb4ahttps://doi.org/10.2147/dmso.s30968
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