Key result
Other enteroviruses have become the predominant pathogens of hand, foot and mouth disease in the North Sichuan region, accounting for 81.08% of cases, while EV-A71 incidence has decreased significantly to 1.48%.
Why the study?
Hand, foot and mouth disease remains an important public health problem in China, but studies on its epidemiological characteristics in the North Sichuan region have been neglected.
Observational (n=599)
No
Other enteroviruses have replaced EV-A71 as the predominant pathogens causing HFMD in the North Sichuan region, highlighting the need for broad-spectrum multivalent vaccines.
Other EVs predominate in North Sichuan HFMD; leaves open need for regional surveillance and confirmatory studies.
Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.
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Xu et al. (2024) conducted an observational in Hand, Foot and Mouth Disease (HFMD) (n=599). Enterovirus serotypes (EV-A71, CV-A16, other EVs) was evaluated on Predominant enterovirus serotype. Other enteroviruses have become the predominant pathogens of hand, foot and mouth disease in the North Sichuan region, accounting for 81.08% of cases, while EV-A71 incidence has decreased significantly to 1.48%.
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