What question did this study set out to answer?

To isolate and characterize the bioactive antiviral component of the blue-green alga Spirulina platensis and determine its mechanism of action against enveloped viruses.

January 1, 1996Journal of Natural Products

Calcium Spirulan, an Inhibitor of Enveloped Virus Replication, from a Blue-Green Alga Spirulina platensis

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Authors

THToshimitsu HayashiToshiba (Japan)KHKyoko HayashiTokai University MMMasaakira MaedaSaitama University

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Implication

In vitro study demonstrates broad enveloped virus inhibition by algal calcium spirulan in cell models, indicating that blocking viral penetration prevents infection.

Key Points

To isolate and characterize the bioactive antiviral component of the blue-green alga Spirulina platensis and determine its mechanism of action against enveloped viruses.
Performed bioactivity-directed fractionation of hot water extracts from Spirulina platensis to isolate the active antiviral compound calcium spirulan (Ca-SP).
Characterized the chemical composition of Ca-SP and tested its inhibitory activity against enveloped viruses, including HSV-1, HCMV, measles, mumps, influenza A, and HIV-1.
Evaluated the stage of viral replication targeted by Ca-SP and assessed the structural requirement of calcium chelation with sulfate groups.
Isolated calcium spirulan (Ca-SP), a novel sulfated polysaccharide composed of calcium, sulfate, and ten neutral and acidic monosaccharides.
Demonstrated that Ca-SP selectively suppresses the replication of HSV-1, HCMV, measles virus, mumps virus, influenza A virus, and HIV-1 by blocking viral penetration into host cells.
Identified that the molecular conformation maintained by the chelation of calcium ions with sulfate groups is essential for antiviral activity.

Cite This Study

Hayashi et al. (1996) studied this question.

synapsesocial.com/papers/6a6f606726770c2b8ddff4e9 https://doi.org/10.1021/np960017o

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Implication

In vitro study demonstrates broad enveloped virus inhibition by algal calcium spirulan in cell models, indicating that blocking viral penetration prevents infection.

Calcium Spirulan, an Inhibitor of Enveloped Virus Replication, from a Blue-Green Alga Spirulina platensis

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Implication

Key Points

Cite This Study

Calcium Spirulan, an Inhibitor of Enveloped Virus Replication, from a Blue-Green Alga Spirulina platensis

Discussion

Member takes

Implication

Key Points

Cite This Study

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