Risk factors of major lower limb amputation in symptomatic peripheral artery disease: a retrospective cohort study

AIM: To find risk factors of major amputation in patients with peripheral artery disease (PAD) by a combination of both personal risk factors and treatment. METHODS: This was a retrospective cohort study enrolled adult patients diagnosed as symptomatic PAD. Predictors for major amputation were analyzed. RESULTS: There were 221 patients with PAD met the study criteria; 28 patients (12.67%) had major amputation events. There were three independent factors Rutherford classification, white blood cell, and serum albumin. The adjusted odds ratio (95% confidence interval) of these factors were 1.824 (1.118, 2.976), 1.073 (1.019, 1.131), and 0.421 (0.202, 0.879), respectively. CONCLUSIONS: Serum albumin was modifiable to prevent future major amputation in patients with PAD.