The translational roadmap of the gut models, focusing on gut-on-chip

<ns3:p> It is difficult to model <ns3:italic>in vitro</ns3:italic> the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational research with a focus on gut-on-chip. These micro physiological systems (MPS) are microfluidic devices that recapitulate <ns3:italic>in vitro</ns3:italic> the physiology of the intestine. We reviewed the gut-on-chips that had been developed in academia and industries as single chip and that have three main purpose: replicate the intestinal physiology, the intestinal pathological features, and for pharmacological tests. </ns3:p>