Embryonic heart failure in NFATc1-/- mice is driven by regurgitant flow and diastolic dysfunction rather than contractile failure, demonstrating the utility of in utero ultrasound biomicroscopy for physiological phenotyping.
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Emphasizes diastolic dysfunction over contractile failure in this model; leaves open translation to human congenital valve disease.
Phoon et al. (2004) studied this question.
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