Why the study?
After R-da-EPOCH for PMLBCL, PET/CT prognostic significance may be modulated with frequent false-positives, causing uncertainty regarding radiotherapy omission in D5PSS-4 and management of D5PSS-5.
Does end-of-treatment PET/CT imaging safely guide the omission of consolidative radiotherapy in patients with PMLBCL treated with R-da-EPOCH?
Does end-of-treatment PET/CT imaging safely guide the omission of consolidative radiotherapy in patients with PMLBCL treated with R-da-EPOCH?
End-of-treatment PET/CT safely guides the omission of consolidative radiotherapy in the vast majority of PMLBCL patients treated with R-da-EPOCH.
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Positive EOT-PET after R-da-EPOCH may reflect false positives in PMLBCL; leaves open safe RT omission pending prospective data.
Vassilakopoulos et al. (2022) studied this question.