Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 8, 2018Critical Care Medicine

Early Enteral Nutrition Provided Within 24 Hours of ICU Admission: A Meta-Analysis of Randomized Controlled Trials*

View Full Paper
Ask AI
Bookmark
Share

Authors

FTFeng TianUniversity of Science and Technology of ChinaPHPhilippa T. HeighesRoyal North Shore HospitalMAMatilde Jo AllingstrupRigshospitalet

Discussion

Loading...

Member takes

Implication

Meta-analysis of randomized trials finds early enteral nutrition reduces mortality compared with delayed intake in critically ill adults, suggesting benefits over delayed feeding.

Key Points

  • To determine whether initiating early enteral nutrition within 24 hours of ICU admission improves clinical outcomes, including mortality and infection rates, in critically ill adult patients.
  • Systematic review and meta-analysis of Medline and Embase through November 20, 2017.
  • Identified 16 randomized controlled trials enrolling 3,225 critically ill adult patients admitted to the ICU.
  • Compared early enteral nutrition (standard formula started within 24 hours) against any alternative nutritional support strategy.
  • Early enteral nutrition did not significantly reduce overall mortality compared with all alternative nutrition strategies combined (OR 1.01; 95% CI, 0.86–1.18; p = 0.91; I² = 32%).
  • Early enteral nutrition significantly reduced mortality compared with delayed enteral feeding (OR 0.45; 95% CI, 0.21–0.95; p = 0.038; I² = 0%), but showed no mortality difference compared with parenteral nutrition (OR 1.04; 95% CI, 0.89–1.22; p = 0.58; I² = 30%).
  • Patients allocated to early enteral nutrition had a significantly lower incidence of pneumonia across all trials (OR 0.75; 95% CI, 0.60–0.94; p = 0.012; I² = 48%).

Cite This Study

Tian et al. (2018) studied this question.

synapsesocial.com/papers/6a6f63452163a0a01bc3b079https://doi.org/10.1097/ccm.0000000000003152
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of enteral nutrition initiation time and nutritional adequacy on the prognosis of critically ill adults: systematic review and meta-analysis2026
  2. 2Early enteral nutrition increases 28-day mortality in patients with sepsis who are on invasive mechanical ventilation: A retrospective analysis based on the MIMIC - IV database2024
  3. 3The impact of timing of enteral nutrition initiation on the prognosis of abdominal infection in critically ill patients2025 · 2 citations
  4. 4Effectiveness of registered dietitian-led management of early nutritional support in the emergency intensive care unit: a retrospective observational study2024 · 5 citations
  5. 5Effectiveness of Registered Dietitian-Led Management of Early Nutritional Support in the Emergency Intensive Care Unit: A Retrospective Observational Study2024