What question did this study set out to answer?

April 30, 2025NatureOpen Access

Global evolution of inflammatory bowel disease across epidemiologic stages

View Full Paper

Ask AI

Bookmark

Authors

LHLindsay HracsUniversity of Calgary JWJoseph W. WindsorUniversity of Calgary JGJulia GorospeUniversity of Calgary

Discussion

Member takes

Implication

Global population-based analysis reveals transitions across epidemiologic stages of inflammatory bowel disease in 82 regions, highlighting an escalating worldwide burden.

Key Points

Establish numerical indicators for the four proposed epidemiologic stages of inflammatory bowel disease and characterize its global evolution over time.
Synthesized real-world data from 522 population-based studies spanning 82 global regions between 1920 and 2024.
Evaluated incidence and prevalence metrics to delineate transitions between stages 1 to 3 and applied computational modeling to project stage 4 progression.
Demonstrated empirical spatiotemporal transitions across stage 1 (emergence), stage 2 (acceleration in incidence), and stage 3 (compounding prevalence).
Modeled progression toward stage 4 (prevalence equilibrium), characterizing the plateau effect driven by demographic shifts in aging populations with inflammatory bowel disease.

Cite This Study

Hracs et al. (2025) studied this question.

synapsesocial.com/papers/6a6f63bf78a11c550e09170e https://doi.org/10.1038/s41586-025-08940-0

View Full Paper

Ask AI

Bookmark

Implication

Global population-based analysis reveals transitions across epidemiologic stages of inflammatory bowel disease in 82 regions, highlighting an escalating worldwide burden.

Global evolution of inflammatory bowel disease across epidemiologic stages

Discussion

Member takes

Implication

Key Points

Cite This Study

Global evolution of inflammatory bowel disease across epidemiologic stages

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider