C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach
Why the study?
Does genetically elevated plasma CRP cause an increased risk of COPD or COPD hospitalization in the general population?
Population
40,626 individuals
Comparison
Genetically elevated plasma CRP vs Lower or normal genetically determined plasma CRP
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Observational CRP-COPD links likely noncausal; leaves open CRP as therapeutic target pending randomized confirmation.
Structured PICO
Does genetically elevated plasma CRP cause an increased risk of COPD or COPD hospitalization in the general population?
P
Population
40,626 individuals (7,974 from the Copenhagen City Heart Study and 32,652 from the Copenhagen General Population Study)
I
Intervention
Genetically elevated plasma CRP (based on four single nucleotide polymorphisms in the CRP gene)
C
Comparator
Lower or normal genetically determined plasma CRP
O
Outcome
Spirometry-defined COPD and hospitalization due to COPDhard clinical
Genetically elevated plasma CRP is not associated with an increased risk of clinical COPD, suggesting the observational association between CRP and COPD is not causal.
Cite This Study
Dahl et al. (2010) studied this question.