Why the study?
Does treatment with a mAb against LFA-1 prevent the death of transplanted myoblasts in mice?
Does treatment with a mAb against LFA-1 prevent the death of transplanted myoblasts in mice?
Controlling the nonspecific inflammatory reaction with anti-LFA-1 and specific immune response with FK506 significantly increases the success of myoblast transplantation in a mouse model.
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May improve myoblast engraftment in immunosuppressed mice; leaves open translation to clinical cell therapy.
Guérette et al. (1997) studied this question.
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