Population
Purified vinculin, tail domain, F-actin, and talin
Comparison
Phosphatidylinositol 4,5-bisphosphate /… vs Control conditions
Design
Preclinical
Authors
Loading...
PI4,5P2 binding alone insufficient for vinculin activation; leaves open additional steps required in cellular contexts.
Activation of the actin-binding activity of vinculin requires steps other than or in addition to the binding of PI4,5P2.
Steimle et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: