Why the study?
Damaged heart tissue from cardiovascular disease has limited regenerative capacity, but emerging evidence shows long noncoding RNAs play critical roles in CVD pathogenesis and myocardial regeneration.
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Design
Review
This review highlights the emerging molecular mechanisms of lncRNAs in cardiovascular disease and their potential as novel RNA-based therapeutic targets for cardiac repair and regeneration.
Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated cardiomyopathy, myocardial infarction, heart fibrosis, and genetic and developmental heart defects such as heart valve deformities. Damaged or defective heart tissue has limited regenerative capacity and results in a loss of functioning myocardium. Advances in transcriptomic profiling technology have revealed that long noncoding RNA (lncRNA) is transcribed from what was once considered "junk DNA." It has since been discovered that lncRNAs play a critical role in the pathogenesis of various CVDs and in myocardial regeneration. This review will explore how lncRNAs impact various forms of CVD as well as those involved in cardiomyocyte regeneration. Further, we discuss the potential of lncRNAs as a therapeutic modality for treating CVD.
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Kim et al. (2023) studied this question.
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