Key result
Cell type-specific microRNA therapies show promise for myocardial recovery after infarction despite translational hurdles.
Review evaluates cell type-specific microRNA therapies for damaged myocardium after infarction, highlighting emerging strategies for cardiac repair.
Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.
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Liu et al. (2021) conducted a review in myocardial infarction. microRNA therapies was evaluated. Cell type-specific microRNA therapies offer a promising strategy to recover injured myocardium after infarction by controlling gene expression, despite outstanding translational challenges.
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