Why the study?
Does ST-segment depression with a negative T wave in leads V4-5 predict severe coronary artery disease and worse in-hospital prognosis in patients with non-ST-elevation acute coronary syndrome?
Population
50 consecutive patients with non-ST-elevation acute coronary syndrome and elevated troponin levels
Comparison
ST-segment depression and a negative T wave… vs ST-segment depression and a positive T wave in…
Design
Cohort
Follow-up
in-hospital
Authors
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May flag high-risk NSTE-ACS for urgent evaluation; hypothesis-generating and should not yet change practice.
Does ST-segment depression with a negative T wave in leads V4-5 predict severe coronary artery disease and worse in-hospital prognosis in patients with non-ST-elevation acute coronary syndrome?
In patients with NSTE-ACS, transient ST-segment depression with a negative T wave in leads V4-5 during pain is a strong predictor of severe left main or three-vessel coronary artery disease and higher in-hospital mortality.
Nikus et al. (2004) studied this question.
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